Hi,
Yes, this should be possible, via using a custom field filter, as ACF fields are post meta fields. For all the details about the custom field filters you can find in this documentation.
In your case, it should look something like this:
1. Creating the custom field filter: https://i.imgur.com/qw6MCUg.png
Make sure that the field name and the type is correct, according to your case.
2. You can hide the front-end options, and the filter will be still active, but invisible: https://i.imgur.com/3M1l691.png
