Okay, that reveals, that the file required for the analytics code was removed from the queue. With the classic settings everything is enqueued as a single file, so it includes the analytics handler.
That may point to a 3rd party code conflict of some sort, as I can’t replicate the same issue with the same optimized settings on a test environment, I double checked the code as well, and everything seem to be okay there.
Can you please tes the “Optimized” and the “Optimized Asynchronous” settings separately as well? Let me know if there is any difference.